Cicatricial ectropion due to herpes zoster ophthalmicus.

Osteogenesis imperfecta (OI) or Brittle bone disease is the most common genetic cause of osteoporosis. The OI is caused by structural or quantitative defect in type I collagen. OI has the triad of fragile bone, blue sclerae and early deafness. O1 type V is characterized by recurrent multiple fractures in a child following ambulation with hyperplastic callus formation at the sites of fracture. This may be associated with calcification of introsseus membrane of forearm and a radidsense metaphyseal band. The diagnosis is usually clinical and may be confirmed by collagen biochemical studies using fibroblast cultured from a skin punch biopsy.